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Basic variant consequence annotation
Insilico predictions of effect of coding variants
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dBNSFP -
database of non-synonymous functional predictions (v5.0, January
2025)
Variant frequency databases
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gnomAD - germline
variant frequencies exome-wide (r2.1.1 (non-cancer subject allele
frequencies), r4.1)
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dbSNP - database of
short genetic variants (build 156)
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Cancer Hotspots - a resource
for statistically significant mutations in cancer (v2, 2017)
Variant databases of clinical utility
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ClinVar -
database of clinically related variants (March 2025)
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CIViC - clinical interpretations
of variants in cancer (March 13th 2025)
Protein domains/functional features
Cancer gene knowledge bases
