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Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar)

Source: R/predisposition_gene.R
append_cpg_properties.Rd

Function that appends mechanism-of-inheritance (MOI) and mechanism of disease (MOD) annotations to cancer predisposition genes (cpg's), as well as estimated fractions of truncation vs. non-truncating variants etc per predisposition gene (from ClinVar)

Usage

append_cpg_properties(cpg_calls, ref_data = NULL)

Arguments

cpg_calls

data frame with variant calls in predisposition genes

ref_data

PCGR/CPSR reference data object

Value

cpg_calls data frame with cancer predisposition gene properties appended (mechanism of disease, inheritance patterns etc)