Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar)

Function that assigns final pathogenicity classification (B, LB, VUS, P, LP) based on accumulated scores from different ACMG criteria and pre-defined cutoffs (calibrated against ClinVar)

Usage

assign_classification(cpg_calls)

Arguments

cpg_calls

data frame with variant calls in predisposition genes

Value

cpg_calls data frame with pathogenicity classification appended